In 1822, Denmark Vesey and other leaders of the AME church began plotting a rebellion to achieve liberation for the enslaved in Charleston. He envisioned the rebellion spreading to other cities and ultimately freeing all enslaved people. Vesey set the date for revolt on July 14; men from Charleston and surrounding plantations planned to seize Charleston's arsenals and set fire to the city. But in June several slaves leaked details of the plot to their masters, and authorities began arresting the leaders. Vesey was captured and he and his co-conspirators were brought to trial. On July 2nd, Vesey and five other men were hanged.
Vesey is believed to have established a carpentry business and residence at this Bull Street house prior to the rebellion.